Prof. Dr. Umid Kumar Shrestha
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Prof. Dr. Umid Kumar Shrestha

HoD & Principal Consultant


Umid Kumar Shrestha is an experienced Gastroenterologist and Hepatologist and is the Principal Consultant and Head of the Department of Gastroenterology, Hepatology, and Endoscopy. He has done his MBBS from Rajshahi Medical College (Bangladesh), MD in Internal Medicine from the Institute of Medicine, Tribhuvan University (Nepal), and completed his PhD in Gastroenterology and Hepatology from Wuhan University (China). He was a Berenson Scholar in Advanced Endoscopy at Beth Israel Deaconess Medical Center, Harvard Medical School Teaching Hospital in Boston, USA in 2014. He was elected a Fellow of the American College of Gastroenterology (FACG) in 2018. He has received a molecular cancer prevention course under the Cancer Prevention Fellowship Program from the National Cancer Institute, NIH, USA. He was formerly associated to Manipal Teaching Hospital, Pokhara, Nepal as the Professor of Medicine and Chief of the Internal Medicine II and Division of Gastroenterology and Endoscopy.

He is a chief editor of the peer-reviewed medical journals “Nepal Mediciti Medical Journal” and “Journal of Advances in Internal Medicine”. He has published several research papers in renowned national and international journals. His research works about gastrointestinal diseases have been published in renowned international medical journals such as ‘Inflammatory Bowel Diseases’ (official journal of the Crohn's & Colitis Foundation, USA), ‘Digestive Diseases and Sciences’, ‘Genes and Immunity’, ‘Clinica Chimica Acta’, etc. He has also published research papers on non-alcoholic fatty liver disease and metabolic syndrome in ‘The Journal of Endocrinological Investigation’ (Official Journal of Italian Society of Endocrinology) and ‘Menopause’ (the Journal of North American Menopause Society). He has been a peer reviewer of international journals such as ‘The American Journal of Gastroenterology’, ‘Journal of Gastroenterology and Hepatology’, ‘European Journal of Gastroenterology and Hepatology’, ‘Scandinavian Journal of Gastroenterology’, ’BioMedCentral journal, Trials, etc. 

He has presented his papers in Digestive Disease Week (DDW, USA) in 2009 and 2010, at the American College of Gastroenterology (ACG, USA) in 2014, and at the World Congress of Gastroenterology (WCOG, Turkey) in 2019. He has contributed with several unique endoscopic pictures for the Endoscopic Slide Atlas of GastroHep.com, published by Wiley-Blackwell Publication of USA.

 


Education

Area of Focus

  • Interventional endoscopy (ERCP, EUS, etc)
  • Non-invasive and Invasive Gastroenterology and Hepatology

Language spoken

  • ENGLISH
  • NEPALI
  • HINDI
  • NEWARI
  • CHINESE

Berenson International Scholar in Advanced Endoscopy (including ERCP, Endoscopic Ultrasound) from Beth Israel Deaconess Medical Center, Harvard Medical School Teaching Hospital, Boston, USA

Fellow of American College of Gastroenterology (FACG) 

Cancer Prevention Fellowship Program in Molecular Cancer Prevention from National Cancer Institute, National Institutes of Health, MD, USA

  • Peptic Ulcer Disease, Gastroesophageal Reflux Disease (GERD)
  • Cirrhosis of liver, acute liver failure, drug-induced liver injury, non-alcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune and cholestatic liver disease, Liver Transplant Workup
  • Cholangitis, bile duct stones
  • Chronic pancreatitis, acute pancreatitis, cysts in pancreas
  • Inflammatory Bowel Disease (Ulcerative Colitis, Crohn’s Disease)
  • Irritable Bowel Syndrome (IBS), celiac disease and  non-celiac gluten sensitivity
  • Colon Polyps, Colorectal Cancer
  • Abdominal tuberculosis

 

  1. A study on demographic and clinicopathological characteristics of severe acute pancreatitis in a tertiary-level intensive care unit in Nepal, Journal of Advances in Internal Medicine - 2023; 12(1):1-4
  2. Osler‐Weber‐Rendu syndrome: A case report on a rare vascular malformation presented with lower gastrointestinal bleeding, Clinical Case Reports - 2023; 11(2)
  3. Global Biologic Characteristics of Variants of Concern and Variants of Interest of SARS-CoV-2. In: Adibi, S., Griffin, P., Sanicas, M., Rashidi, M., Lanfranchi, F. (eds) Frontiers of COVID-19. Springer, Cham. 2022; 161–181.
  4. B.1.617.2 variant and increasing surge of COVID-19 in Nepal. Nepal Mediciti Medical Journal 2021;2(1):1-4.
  5. SARS-CoV-2 vaccines and their challenges against the variantsJournal of Advances in Internal Medicine 2021;10(1):1-3.
  6. Outcome of Pneumatic Balloon Dilatation in Achalasia CardiaJournal of Advances in Internal Medicine 2021;10(1):8-13.
  7. Adaptive immunity against COVID-19Journal of Advances in Internal Medicine 2020;9(2):44-46.
  8. Impact of COVID-19 on community health: A systematic review of a population of 82 millionJournal of Advances in Internal Medicine 2019;8(2):4-11.
  9. Endoscopic resection of a giant symptomatic Brunner’s gland hamartoma of duodenal bulb. Journal of Advances in Internal Medicine 2019;8(2):30-32.
  10. Ligation assisted endoscopic mucosal resection of neuroendocrine tumor of duodenal bulb: a case report with a follow up of 24 monthsJournal of Advances in Internal Medicine 2019;8(1):18-20.
  11. Endoscopic resection of a giant symptomatic Brunner’s gland hamartoma of duodenal bulb, saving from unnecessary pancreaticoduodenectomy. Conference paper. Turkish Journal of Gastroenterology 2019; 30(Suppl 3): S802
  12. Endoscopic mucosal resection of neuroendocrine tumor of duodenal bulb by band ligation technique: a case report with a follow up of 18 months. Conference paper. Turkish Journal of Gastroenterology 2019; 30(Suppl 3): S823
  13. Double pyloric ostium, an extremely rare endoscopic finding, in a 62-year-old male patient presenting with melenaJournal of Advances in Internal Medicine 2018;7(2):47.
  14. Endoscopic Mucosal Resection of gastric dysplastic lesion by band ligation technique. Journal of Advances in Internal Medicine 2017;6(1):9-10.
  15. Etiological profile of benign esophageal stricture and its management with through-the-scope endoscopic balloon dilation in the western region of Nepal. Journal of Advances in Internal Medicine 2016;5(2):44-48.
  16. Seroprevalence of hepatitis B virus, hepatitis C virus and human immunodeficiency virus along with their demographic and biochemical profile among the patients in the western region of Nepal. Journal of Advances in Internal Medicine 2016;5(1):15-18.
  17. Clinical profile of 103 patients with abdominal tuberculosis in Nepal. Journal of Advances in Internal Medicine 2015;4(2):51-56.
  18. Predictors of in-hospital mortality of very elderly patients in the western region of Nepal. Journal of Disease and Global Health 2016;7(3):2454-1842.
  19. Prevalence of nonalcoholic fatty liver disease and its metabolic risk factors in women of different ages and body mass index. Menopause 2015;22(6):667-673.
  20. Profiles of heart failure in the western region of Nepal: prognostic implications of the MELD-XI score. Internal Medicine Inside 2015;3(1):1-5.
  21. Etiological profile, gender difference and age group patterns of 415 patients presenting with lower gastrointestinal bleeding in the western region of Nepal. Journal of Advances in Internal Medicine 2015;3(2):52-55.
  22. Immunology of the gut and oral tolerance. Journal of Advances in Internal Medicine 2015;4(1):16-24.
  23. Prevalence and Gender Difference of Gastrointestinal Cancers and Polyps in Patients Presenting With Gastrointestinal Bleeding in Nepal. The American Journal Of Gastroenterology 2014;109(S2):S601.
  24. Etiology and adverse outcome predictors of upper gastrointestinal bleeding in 589 patients in Nepal. Digestive Diseases and Sciences 2014;59(4):814-822.
  25. Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal. Journal of Advances in Internal Medicine 2013;2(2):52-60..
  26. Impaction of food material wrapped in a plastic sheet in a huge intraluminal duodenal diverticulum. Journal of Advances in Internal Medicine 2013;2(1):14-5.
  27. Does aspirin really reduce the colorectal cancer risk? Journal of Advnaces in Internal Medicine 2013;2(1):1-2.
  28. Role of altered gut microbiota in the development of obesity, insulin resistance and type 2 diabetes mellitus. Nepal Journal of Medical Sciences 2013;2(1):1-2.
  29. First presentation of Ebstein’s anomaly in an 80-year-old female patient and unusual occurrence of psychiatric illness in her male offsprings. Journal of Advances in Internal Medicine. 2013;2(1):1-2.
  30. Familial adenomatous polyposis in a young adult with amoebic dysentery. GastroHep slide atlas; gastrohep.net. Blackwell Publishing. Available in internet on December 17, 2012.
  31. False esophageal diverticulum caused by impaction of a chicken bone. GastroHep slide atlas; gastrohep.net. Blackwell Publishing. Available in internet on December 17, 2012.
  32. Charred gastric mucosa in formalin poisoning. GastroHep slide atlas; gastrohep.net. Blackwell Publishing. Available in internet on September 25, 2012.
  33. Underestimation of clinical importance of non-steroidal anti-inflammatory drug induced enteropathy and its exacerbation by proton pump inhibitors. Journal of Advances in Internal Medicine 2012;1(2):50-1.
  34. An elderly patient of formalin poisoning presenting with hematemesis. Journal of Advances in Internal Medicine 2012;1(2):64.
  35. Fasting serum lipids and fundus changes in hypertensive patients. Nepal Journal of Medical sciences 2012;1(2):103-7.
  36. Role of Peroxisome Proliferator Activated Receptor-gamma and its Ligands in Inflammatory Bowel Disease. Journal of Advances in Internal Medicine 2012;1(1):33-8.
  37. Non-Alcoholic Fatty Liver Disease (NAFLD) - Is it an Emerging Risk Factor for Coronary Artery Disease? Journal of Advances in Internal Medicine 2012;1(1):2-3.
  38. Colorectal cancer protection and Colonoscopy. Nepal Journal of Medical Sciences 2012;1(1):1-2.
  39. Gender difference in frequency of conventional risk factors in patients with acute coronary syndromes admitted in Manipal Teaching Hospital. Nepal Journal of Medical Sciences 2012;1(1):31-4.
  40. A case of Polyneuropathy following a single dose of Diethylcarbamazine and Albendazole during mass administration of drug - A case report. Nepal Journal of Medical Sciences 2012;1(1):56-8.
  41. The prevalence and diagnostic value of anti-neutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in Chinese Patients with Inflammatory Bowel Disease. Clinica Chimica Acta 2010;411(19-20):1461-5.
  42. CTLA4 -1661A/G and 3’UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expressions. Genes & immunity 2010;11(7):573-83. 
  43. Multidrug resistance reversal by curcumin in multiple myeloma cell line MOLP-2/R through FA/BRCA pathway. Annals of Hematology 2010;89(4):399-404.
  44. Distribution of Peroxisome proliferator-activated receptor-gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease. Inflammatory Bowel Diseases 2010;16(2):312-9.
  45. CTLA4 -1661a/G and 3'Utr Long Repeat Polymorphisms are Associated With Ulcerative Colitis, Regulate CTLA4 mRNA Stability and Influence mRNA and Protein Expressions. Gastroenterology 2010;138(5, Suppl 1)S-679.
  46. Evolution of novel non-steroidal anti-inflammatory drugs with reduced gastrointestinal adverse effects. Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry 2009;8(3):270-278. 
  47. CTLA4 −1661a/G and 3'Utr Long Repeat Polymorphisms are Associated With Ulcerative Colitis, Regulate CTLA4 mRNA Stability and Influence mRNA and Protein Expressions. Gastroenterology  2010;138(5, suppl 1) S-679.
  48. Association of peroxisome proliferator-activated receptor-gamma Pro12Ala and C161T polymorphisms with ulcerative colitis in Chinese population. Gastroenterology 2009;136(5,Suppl 1)A-211.
  49. The prevalence and discrimination value of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies in a Chinese inflammatory bowel disease cohort in central China. Gastroenterology 2009;136(5,Suppl 1)A-353.
  50. Correlation of peroxisome proliferator-activated receptor-gamma Pro12Ala and C161T polymorphisms with ulcerative colitis. Journal of Clinical Internal Medicine [Linchuang Neike Zazhi] 2009;26(4):254-256 [article in Chinese language with abstract in English]. 
  51. Correlation between adiponectin gene polymorphism and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population. Journal of Endocrinological Investigation 2008; 31(12):1086-1091.
  52. The prevalence of hypertension and diabetes defined by fasting and 2-h plasma glucose criteria in urban Nepal. Diabetic Medicine 2006;23(10):1130–1135.
  53. Postvaccinal encephalomyelitis and MRI changes. Journal of Institute of Medicine 2001;23(1-2):78-81.

 

PRESENTATION:

  1. EUS for indeterminate biliary stricture. ENDOSAARC 22 Borderless Doctor's symposium, held on December 17-18, 2022, organized by B P Koirala Institute of Health Sciences, Dharan, Nepal
  2. Video capsule endoscopy for suspected small bowel bleeding. National Conference on Science and Technology held on June 26 - 28, 2022, organized by Nepal Academy of Science and Technology, at NAST Complex, Khumaltar, Lalitpur, Nepal
  3. Abdominal tuberculosis - the dilemmas. TUTH Gastro Update 2022, on April 9, 2022, organized by Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal
  4. Chronic pancreatitis: Surgeon vs Gastroenterologist. International Endoscopy Workshop, 18-19 November 2021, organized by Dhulikhel Hospital, Nepal and Gastro-foundation, Germany.
  5. COVID-19: treatment and management. International webinar on Global impact of COVID-19. Mahatma Gandhi University, 20 June 2020, Kerala, India
  6. Use of image enhanced endoscopy in diagnosis of colonic polyps. Bir Gastro Update 2020 on February 22, 2020, organized by Bir Hospital, NAMS, Kathmandu, Nepal
  7. Endoscopic resection of a giant symptomatic Brunner’s gland hamartoma of duodenal bulb, saving from unnecessary pancreaticoduodenectomy. World Congress of Gastroenterology, 21-24 September 2019, Istanbul, Turkey.
  8. Endoscopic mucosal resection of neuroendocrine tumor of duodenal bulb by band ligation technique: a case report with a follow up of 18 months. World Congress of Gastroenterology, 21-24 September 2019, Istanbul, Turkey.
  9. Fatty liver management. Panelist: International Liver Conclave, 15 April 2020, Kathmandu, Nepal.
  10. Stenting in GI practice. TUTH Gastro Update 2019 on February 23, 2019, organized by Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal
  11. Portal Hypertensive Enteropathy and its endoscopic intervention. Invited guest lecture for Sixth South Asian Association for the Study of Liver (SAASL) Meeting and 1st Nepalese Association for the Studies of the Liver (NASL) International conference. July 13-14, 2018, Kathmandu, Nepal
  12. Infections as mimickers of inflammatory bowel disease. Third National Conference of Society of Internal Medicine of Nepal, February 16-17, 2018, Biratnagar, Nepal.
  13. Management of variceal bleeding. Gastro Update 2017 on December 30, 2017, organized by National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal
  14. Endoscopic management of gastrointestinal polyps. First International Gastroenterology Conference of Nepal, December 9-11, 2016, Kathmandu, Nepal 
  15. Endoscopic balloon dilatation in patients with benign gastric outlet obstruction: case series. First International Gastroenterology Conference of Nepal, December 9-11, 2016, Kathmandu, Nepal 
  16. Comparison of Deritis Ratio with Pre-existing Scoring System to Assess Severity among Patients with Alcoholic Liver Disease. The Liver Week 2015. September 10-12, 2015; Bexco, Busan, Korea.
  17. Management of a large colon polyp. Guest lecture at the 12th International Conference of Society of Internal Medicine of Nepal (SIMON), April 24-25, 2015, Kathmandu, Nepal. 
  18. Prevalence and Gender Difference of Gastrointestinal Cancers and Polyps in Patients Presenting With Gastrointestinal Bleeding in Nepal. American College of Gastroenterology 2014 Annual Scientific Meeting and Postgraduate Course. October 17-22, 2014; Philadelphia, PA, USA.
  19. Latest update on non-alcoholic fatty liver disease. Guest lecture at the 11th International Conference of Society of Internal Medicine of Nepal (SIMON), April 5-6, 2013, Kathmandu, Nepal. 
  20. Management of esophageal and gastric variceal bleeding: scenario in Nepal. Guest lecture at International workshop on interventional endoscopy, November 10-12, 2013. Dhulikhel, Nepal.
  21. An 80-year-old female Ebstein’s anomaly patient with a history of psychiatric illness in her male off springs. International conference of cardiac society of Nepal. November 2-3, 2012; Kathmandu, Nepal.
  22. Non-cirrhotic portal hypertension in young adults in Nepal: a re-evaluation of 6 patients. Free paper presentation at the 10th National Conference of Society of Internal Medicine of Nepal (SIMON), March 11-12, 2011, Pokhara, Nepal.
  23. Recent changes in the prevalence of Helicobacter pylori infection and its correlation with endoscopic findings in Nepal. Free paper presentation at the 10th National Conference of Society of Internal Medicine of Nepal (SIMON), March 11-12, 2011, Pokhara, Nepal.
  24. CTLA4 -1661A/G and 3'Utr Long Repeat Polymorphisms are Associated With Ulcerative Colitis, Regulate CTLA4 mRNA Stability and Influence mRNA and Protein Expressions. Poster Presentation at the American Gastroenterological Association, Digestive Disease Week, May 1-5, 2010, New Orleans, LA, USA. 
  25. Association of peroxisome proliferator-activated receptor-gamma Pro12Ala and C161T polymorphisms with ulcerative colitis in Chinese population. Poster Presentation at the American Gastroenterological Association, Digestive Disease Week, May 30–June 4, 2009, Chicago, USA.
  26. The prevalence and discrimination value of perinuclear anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies in a Chinese inflammatory bowel disease cohort in central China. Poster Presentation at the American Gastroenterological Association, Digestive Disease Week, May 30–June 4, 2009, Chicago, USA.

Awarded as a Berenson International Scholar in Advanced Endoscopy at Beth Israel Deaconess Medical Center (Harvard Medical School Teaching Hospital), Boston, USA in 2014.

Received Nepal Vidhya Bhushan Gold Medal class ‘A’ for the academic achievement from the president of Nepal in 2009.

Received several awards from different social organizations (Nepal Cancer Relief Society, Patan Jaycees, Nepal Anti-Tuberculosis Association, etc.) for the social service in the community.

Past Affiliations: Professor of Medicine at Manipal Teaching Hospital, Pokhara

Life member of Nepalese Society of Gastroenterologists

Life member of Society of Internal Medicine of Nepal

Life member of Nepal Medical Association

Life member of Nepal Cancer Relief Society

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